Zydelig Dosage Guide: Formulations, Strengths, Usage Instructions, and Additional Information
Zydelig, a brand-name drug, is used to treat relapsed chronic lymphocytic leukemia (CLL) in adults. It comes as an oral tablet that is swallowed whole, typically taken twice per day, and may be taken with or without food.
It is essential to follow the dosage prescribed by your doctor. Do not take more Zydelig than prescribed, and it may be helpful to take it around the same time of day. Zydelig starts to work after your first dose.
However, it is crucial to be aware of the potential side effects of Zydelig, particularly when combined with rituximab (Rituxan). Common side effects include diarrhea and colitis, which can be severe and may lead to intestinal perforation in rare cases. There is an increased risk of infections, including serious infections, hepatotoxicity, pneumonitis, neutropenia, and other cytopenias leading to low blood counts and increased risk of bleeding and infection.
Close monitoring by a healthcare professional is required, particularly for liver function, infections, and gastrointestinal symptoms. Serious and fatal intestinal perforation has been reported with idelalisib, usually alongside moderate to severe diarrhea. Other common adverse effects associated with idelalisib, particularly when combined with rituximab, include increased risk of low blood counts and liver toxicity.
If you believe you've taken too much Zydelig, contact your doctor right away or contact America's Poison Centers at 800-222-1222 or use its online tool. If you have severe symptoms, immediately call 911 or your local emergency number, or go to the nearest emergency room.
It is recommended to use a medication reminder, such as an alarm, note, or app, to help remember to take Zydelig. Do not divide, crush, chew, or place the tablet in water. If you miss a dose, take it as soon as you remember, but if it's been 6 or more hours since your missed dose, skip the missed dose and take your next scheduled dose.
Zydelig is meant to be taken as a long-term treatment. The dosage of Zydelig can vary depending on factors such as how the body responds to the drug, other medications, side effects, liver function, and other medical conditions. If you have trouble swallowing tablets, consider consulting an article, your doctor, or pharmacist for tips.
Zydelig is prescribed along with rituximab for adults who can take Rituxan on its own. It is essential to discuss any concerns about the treatment with your healthcare provider.
Lastly, it is important to note that Zydelig is not available in a generic version, and the dosage of Zydelig isn't similar to the dosage of Venclexta. Some pharmacies offer labels with large print, braille, or a code to convert text to speech.
In brief, patients should be closely monitored for gastrointestinal symptoms, liver toxicity, infections, and hematological abnormalities during treatment with this combination to manage these potentially severe adverse effects effectively.
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