Werewolf Therapeutics Unveils Immune-Stimulating Molecules at SITC's 40th Annual Meeting
Werewolf Therapeutics, a trailblazing biopharmaceutical company, is set to display its state-of-the-art immune-stimulating molecules at the Society for Immunotherapy of Cancer's 40th Annual Meeting. The company's PREDATOR platform facilitates the design of conditionally activated INDUKINETM and INDUCERTM molecules, targeting both adaptive and innate immunity. Werewolf's most advanced clinical stage products, WTX-124 and WTX-330, are conditionally activated Interleukin-2 (IL-2) and Interleukin-12 (IL-12) INDUKINE molecules for solid tumor treatment.
Werewolf will present three posters at the conference, highlighting its innovative approaches. The first poster, to be presented on Nov. 7, 2025, demonstrates the enhanced antitumor activity of sequentially administering WTX-124 and WTX-330 in mice with poorly immunogenic tumors, without causing systemic toxicity. The second poster, on Nov. 8, 2025, reveals the development of conditional T cell engagers, INDUCERTM molecules, with a novel masking approach to reduce dose-limiting cytokine release and off-target peripheral toxicity. The third poster, also on Nov. 8, 2025, provides pharmacokinetic insights into WTX-124, offering real-time assessment of tumor-specific activation and immune modulation. Werewolf's first INDUCER development candidate, WTX-1011, targets STEAP1 for prostate cancer treatment.
Werewolf Therapeutics' presentations at the SITC's 40th Annual Meeting emphasize the company's dedication to advancing immune-based cancer therapies. The posters showcase Werewolf's innovative INDUKINETM and INDUCERTM molecules, presenting promising avenues for solid tumor treatment and immune modulation.
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