Reduction in Skin Aging attributable to components from Bacteria found in Bloodstream.
Modern Science Unearths Skin-Saving Secrets from Bloodstream Bacteria
In the pursuit of eternal youth, people have tried all sorts of potions, lotions, and creams. But what if we told you the key to youthful-looking skin might be hiding right under your nose? That's exactly what a group of researchers has discovered - three anti-aging compounds produced by a bugs residing in your bloodstream!
These miracle workers, known as indole metabolites, can reduce damage and inflammatory responses in human skin cell cultures. The findings, published in the Journal of Natural Products by the American Chemical Society and the American Society of Pharmacognosy, could pave the way for new treatments to beat aging skin woes.
Indole compounds are well-known for their anti-aging, anti-inflammatory, and antimicrobial properties. In 2015, scientists stumbled upon a blood bacterium producing indole compounds, dubbed Paracoccus sanguinis. Researchers Chung Sub Kim, Sullim Lee, and colleagues decided to take a closer look at this little-known bug and uncover its secrets.
The team grew a hefty batch of P. sanguinis for three days and analyzed the mix of metabolites it produced. With a blend of techniques like spectrometry, isotope labeling, and computational analysis, they discovered 12 individual indole metabolites, six of which were never identified before.
But the real question is, can these indole metabolites really take years off your skin? To find out, the researchers applied solutions containing each indole to wells filled with human skin cells treated to induce aging-like conditions. The results? Three of the indoles, including two previously unknown ones, reduced harmful inflammation and collagen damage in the stressed cells!
With these initial findings, the researchers are confident that the new indole metabolites will be promising candidates for future anti-aging treatments. And who knows, maybe the future of skincare lies in your bloodstream after all!
Funding: The authors acknowledge funding from the National Research Foundation of Korea, the BK21 FOUR Project, and the National Supercomputing Center.
Behind the Scenes: Uncovering Nature's Youth Elixir
Author: ACS NewsroomSource: ACSContact: ACS Newsroom - ACSImage: The image is courtesy of our website
Original Research: Closed access."Discovery and Biosynthesis of Indole-Functionalized Metabolites from the Human Blood Bacterium, Paracoccus sanguinis, and Their Anti-Skin Aging Activity" by Chung Sub Kim et al. Journal of Natural Products
Abstract
The human microbiome plays a crucial role in health and disease, with microbial metabolites acting as key mediators of physiological processes. While extensive research has focused on gut-derived microbes, the metabolic contributions of blood-derived bacteria remain underexplored.
In this study, the research team investigates the facultative anaerobe Paracoccus sanguinis, a Gram-negative bacterium isolated from human blood, and its metabolome, revealing insights into its potential impacts on human health.
Using advanced analytical methods, the researchers characterized 12 metabolites, including six novel compounds. Biosynthetic studies demonstrated that these metabolites are derived through enzymatic and nonenzymatic pathways. Functional evaluations revealed significant antiaging activities for some compounds, potentially offering new insights into the functional roles of blood-derived microbiota in human health.
This study elucidates the biosynthetic pathways of P. sanguinis metabolites and their anti-skin aging activity, underscoring their potential in modulating skin health and offering novel insights into the functional roles of blood-derived microbiota in human health.
Note: The specific chemical names of the three newly discovered compounds are not detailed in the available reports. They belong to a broader class of indole compounds that are well-known for their anti-aging, anti-inflammatory, and antimicrobial properties. Future research may explore the potential of these compounds to protect other organs and tissues from age-related damage, expanding their potential uses beyond cosmetic applications to broader health implications.
Sources:1. American Chemical Society (ACS)2. The Journal of Natural Products3. The National Research Foundation of Korea4. The BK21 FOUR Project
- The groundbreaking discovery of anti-aging compounds, indole metabolites, produced by a bloodstream bacterium, Paracoccus sanguinis, could revolutionize the field of neuroscience news, especially in relation to health-and-wellness and medical-conditions.
- With properties that include reducing inflammation and collagen damage in stressed skin cells, these indole metabolites might offer potential therapies-and-treatments for aging skin woes, shifting the paradigm of skin-care products.
- Researchers in the field of neuroscience are particularly interested in the anti-inflammatory properties of indole metabolites, as chronic stress is a common contributor to aging and various medical-conditions, and inflammation plays a significant role in that process.
- As the discovery of these indole metabolites opens new doors in neuroscience, further investigations are necessary to explore their potential impact on aging processes not only in the skin but also in other organs and tissues.
- Additionally, this research emphasizes the importance of understanding the role of the microbiome in overall health and wellness, and the potential benefits that may arise from uncovering the secrets hidden within our bloodstream.
