Rare Gene Variant Linked to Higher Type 2 Diabetes Risk Discovered
Scientists from the University of Greifswald have made a significant discovery, identifying genetic variants linked to both testosterone levels in men and type 2 diabetes risk. This breakthrough, published in Nature Communications, could pave the way for improved understanding and management of the condition.
The study, funded by the Medical Research Council and UK Biobank, analysed the complete DNA sequences of over 20,000 genes in more than 200,000 adults. This comprehensive approach allowed researchers to identify rare genetic variants in the GIGYF1 gene, which controls insulin and cell growth factor signaling. These variants were found to significantly impact type 2 diabetes risk.
Carriers of these variants, which occur in around one in 3,000 people, saw their risk of type 2 diabetes increase from a typical 5% to around 30%. Moreover, these variants were also linked to signs of aging such as weaker muscle strength and increased body fat. The discovery suggests that GIGYF1 could be a promising target for future studies and interventions.
The Greifswald research team's findings, detailed in the study with DOI 10.1038/s41467-021-24504-y, highlight the potential of rare genetic variants in understanding and managing type 2 diabetes. Further investigation into the GIGYF1 gene could lead to new strategies for prevention, diagnosis, and treatment of the condition.
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