Oral Bacteria May Influence Your Brain Function
In the realm of medical research, a fascinating connection is being explored between oral health and Alzheimer's disease. This connection revolves around a bacterium known as Porphyromonas gingivalis, or Pg, and an experimental drug called COR388.
Pg, a known organism residing in the human mouth, has been found to cause harm in other parts of the body and has been linked to several serious health issues, including Alzheimer's disease. This bacterium, which thrives in the mouth, can sneak across the blood-brain barrier and cause pathological changes in the brain.
Researchers at the University of Louisville School of Dentistry, led by Dr. Richard J. Lamont, are investigating the role of Pg in Alzheimer's disease. Their work has shown that when mice were orally infected with Pg, the same DNA fingerprint was discovered in their brains, as well as the changes typically seen in people with Alzheimer's disease.
While the exact mechanisms are still being unravelled, it is believed that Pg contributes to the disease by breaking down proteins associated with the brain, such as tau and amyloid-beta. This breakdown leads to the formation of plaques and tangles, characteristic of Alzheimer's disease.
In an effort to combat Pg, COR388, currently in phase 1 clinical trials for Alzheimer's disease, has shown promise. This experimental drug has the ability to neutralize gingipains, enzymes produced by Pg, and block Pg brain infection. In animal studies, researchers have observed that COR388 can reduce the level of Pg DNA and prevent the pathology typical for Alzheimer's disease from developing in the brains of infected animals.
Maintaining good oral hygiene is also crucial in this battle. Rinsing with water after meals helps buffer the collection of bacteria until you can brush, while flossing helps dislodge bits of food that would otherwise collect bacteria and contribute to inflammation and infection on the gums. However, mouthwash, which is too disruptive to the oral microbiome, may hinder the growth of good bacteria.
The human mouth is home to over 6 billion microorganisms, including 700 different species. Johnson & Johnson is using donated saliva from its employees to replicate the oral microbiome and all 700 of its species in a lab. This research underscores the importance of preserving the delicate balance of bacteria in the mouth for overall health.
Chronic gum disease or other oral infections can cause the breakdown of the biological width, a protective gasket around the base of each tooth. This breakdown can lead to more severe health issues, including Alzheimer's disease. Eating high-fiber foods, particularly fruits and vegetables, can help reduce the progression of gum disease by promoting a healthy oral microbiome.
As research continues, the link between oral health and Alzheimer's disease is becoming increasingly clear. By maintaining good oral hygiene and seeking treatment for oral infections, individuals may be able to reduce their risk of developing this devastating disease.
Read also:
- Abu Dhabi initiative for comprehensive genetic screening, aiming to diagnose over 800 conditions and enhance the health of future generations in the UAE.
- Elderly shingles: Recognizing symptoms, potential problems, and available treatments
- Exploring the Reasons, Purposes, and Enigmas of Hiccups: Delving into Their Origins, Roles, and Unsolved Aspects
- Various forms of cataracts include nuclear, pediatric, traumatic, and additional types
