Ketogenic Diet Supplement Safe and Well-Tolerated in Children with Angelman Syndrome
A small clinical trial has found a dietary supplement, designed to mimic a ketogenic diet, to be safe and well-tolerated in youngsters with Angelman syndrome. The study, involving 14 youngsters aged 4 to 11, found that the supplement, called ketogenic medical food formulation (KF), led to consistent improvements in constipation for most participants.
The trial, conducted in four phases over 16 weeks, aimed primarily to assess the supplement's tolerability. All 13 youngsters who completed the study accepted and tolerated the powder formulation. Only two adverse events were reported, indicating the supplement's safety.
The supplement contains high levels of ketones, which may have provided benefit in some cases, although its efficacy could not be determined due to the small number of participants. Half of the families chose to continue using the formula after the study concluded, suggesting potential long-term use and satisfaction.
The clinical trial of the ketogenic medical food formulation (KF) in youngsters with Angelman syndrome has shown promising results in terms of safety and tolerability. While the supplement's efficacy remains inconclusive due to the small sample size, further research is warranted to explore its potential benefits for managing symptoms in this population.
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