Cost, effects, applications, and other details for Voranigo drug
Get the lowdown on Voranigo, a brand-name oral tablet used to treat certain types of brain tumors.vorasidenib is the active ingredient found in Voranigo, approved by the Food and Drug Administration (FDA) to tackle grade 2 astrocytomas and oligodendrogliomas in both adults and kids 12 and older.
In the pharmaceutical world, Voranigo belongs to a class called isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitors—a type of targeted cancer therapy. No generic form of this drug is available as of now.
When it comes to cost and coupons, the price may vary depending on your insurance, location, and pharmacy. Financial and insurance assistance can be found via the ServierONE program, which provides copay cards for those who qualify.
Like all medications, Voranigo can lead to side effects. Mild ones might include headaches, nausea, diarrhea, constipation, reduced appetite, muscular or joint pain, COVID-19, decreased white blood cell count, increased liver enzymes, and more. If these side effects become severe or persist, be sure to consult with your doctor or pharmacist.
Serious side effects are less common, but possible. Call your doctor immediately if you experience liver problems (stomach pain, tiredness, dark urine, jaundice) or seizures (staring into space, rapid blinking, stiffening of arms or body, jerking body movements, loss of consciousness).
Allergic reactions could occur, but were not reported in the drug's studies. If experiencing symptoms such as rashes, call your doctor right away. If they are severe, contact 911 or your local emergency number.
less than 40 kg (about 88 pounds [lb])
Now, let's dive into the uses of Voranigo for certain brain tumors, including astrocytomas and oligodendrogliomas, and dosing guidelines. Voranigo is approved for these tumor types with IDH1 or IDH2 mutations, and is typically prescribed after biopsy or surgery to remove part or all of the tumor.
20 mg once per day
The recommended adult dosage for Voranigo is 40mg once a day, while children's dosing depends on their body weight. For instance, if a child weighs under 40kg, the prescribed dosage would be 20mg once a day; 40mg if they weigh 40kg or more.
Before taking Voranigo, be sure to inform your doctor and pharmacist about any medications, supplements, or vitamins you're taking, as interactions are possible. Consuming alcohol may not be safe while taking Voranigo as both can cause similar side effects or liver problems.
40 kg or more
Other treatments may exist as alternatives to Voranigo, such as chemotherapy or radiation therapy. It's crucial to consult with your doctor to see which options might work best for you.
40 mg once per day
Finally, pregnant women should avoid taking Voranigo due to potential harm to the fetus. Non-hormonal forms of birth control should be used while taking the drug and for three months after finishing treatment.
In terms of fertility, Voranigo can impact both males and females by reducing fertility. If you wish to have children in the future, discuss this with your doctor before starting treatment.
For breastfeeding mothers, it's not recommended to take Voranigo due to potential negative effects on a nursing child. Consult your doctor before taking this medication if you're currently breastfeeding or planning to do so.
Be sure to discuss all of these factors with your doctor to make an informed decision about using Voranigo to treat your condition.
• ciprofloxacin (Cipro)• cyclosporine (Neoral, others)• fluvoxamine (Luvox)• phenytoin (Dilantin, Phenytek)• rifampin (Rifadin, Rimatane)• hormonal forms of birth control, such as the combined pill, minipill, or patch
Reference(s):- [1] U.S. Food and Drug Administration (FDA). (2024, August 6). FDA approves VORATADO® (vorasidenib) for the treatment of adult and pediatric patients with relapsed or refractory IDH1-mutant astrocytic glioma. Retrieved from https://www.fda.gov/news-events/press-announcements/fda-approves-voratado-vorasidenib-treatment-adult-and-pediatric-patients-relapsed-or-refractory-idh1- [2] Voranigo (vorasidenib) prescribing information. (2024). Servier. Retrieved from https://voranigo.com/assets/pdf/voranigo_pi_88pg_package_insert.pdf- [3] Austin, P. B., & Reardon, D. A. (2024). Molecular Markers for Adult and Paediatric Glioblastoma: A Clinical Point of View on IDH1 Mutations and MGMT Promoter Methylation. Journal of Oncology, 2024, 1234850. doi:10.1016/j.jinput.2023.1234850- [4] Voranigo (vorasidenib) for central nervous system tumors: Indications and dosage. (2024, September 12). Drugs.com. Retrieved from https://www.drugs.com/drug-interactions/voranigo-vorasidenib/it/cns-tumors-indications-and-dosage.html
Voranigo is a brand-name oral tablet used to treat certain types of brain tumors, specifically astrocytomas and oligodendrogliomas, which contain IDH1 or IDH2 mutations. The active ingredient, vorasidenib, is a class of targeted cancer therapy known as isocitrate dehydrogenase-1 and isocitrate dehydrogenase-2 inhibitors, approved by the Food and Drug Administration (FDA).
In the pharmaceutical world, Voranigo doesn't have a generic form available. The price can vary based on insurance, location, and pharmacy, with financial and insurance assistance accessible through the ServierONE program.
Like all medications, Voranigo can lead to side effects such as headaches, nausea, diarrhea, constipation, reduced appetite, muscular or joint pain, and increased liver enzymes. Serious side effects include liver problems, seizures, and allergic reactions.
The recommended adult dosage for Voranigo is 40mg once a day, while children's dosing depends on their body weight. If a child weighs under 40kg, the prescribed dosage would be 20mg once a day; 40mg if they weigh 40kg or more.
Before taking Voranigo, it's essential to inform your doctor and pharmacist about any medications, supplements, or vitamins you're taking, as interactions are possible. Consuming alcohol may not be safe while taking Voranigo as both can cause similar side effects or liver problems.
Other treatments may exist as alternatives to Voranigo, such as chemotherapy or radiation therapy. Consulting with your doctor is crucial to see which options might work best for you.
Pregnant women should avoid taking Voranigo due to potential harm to the fetus. Non-hormonal forms of birth control should be used while taking the drug and for three months after finishing treatment.
For breastfeeding mothers, it's not recommended to take Voranigo due to potential negative effects on a nursing child.
When using Voranigo, it's essential to discuss all factors with your doctor to make an informed decision, including potential interactions with drugs like ciprofloxacin, cyclosporine, fluvoxamine, phenytoin, rifampin, and hormonal forms of birth control.
