Blood Pressure Management: Novel Medicine Demonstrates Promising Outcomes
Breakthrough in High Blood Pressure Treatment: Lorundrostat Shows Promise
Get your blood pressure under control - a new, game-changing treatment is on the horizon! Lorundrostat, an aldosterone synthase inhibitor, has shown fantastic results in a global clinical trial, offering hope for individuals with hard-to-manage hypertension.
Consider this: 15% of people with hypertension have abnormal aldosterone regulation. Elevated aldosterone can lead to high blood pressure, posing a significant risk for heart disease, heart attacks, and strokes. The Phase 3 Launch-HTN study unveiled that lorundrostat, by targeting CYP11B2, the enzyme driving aldosterone production, safely and consistently lowered blood pressure in a diverse group of patients who hadn't responded to conventional treatments.
"The Launch-HTN trial is the largest phase 3 hypertension study with a novel drug," explains Manish Saxena, MD, the study's lead Investigator. "Lorundostat has a good safety profile and consistently lowered blood pressure across all of our patient groups."
Resistant hypertension poses a challenge - it's a form of high blood pressure that remains uncontrolled despite maximum doses of multiple medications. With promising findings, lorundrostat may serve as a novel weapon against this refractory condition.
The study, presented at the 34th European Meeting on Hypertension and Cardiovascular Protection, demonstrated meaningful and sustained reductions in systolic blood pressure. Lorundrostat reduced systolic pressure by 16.9 mmHg at Week 6 and by 19 mmHg at Week 12, delivering significant and clinically meaningful blood pressure reductions.
So, how does lorundrostat work?
"Hormone aldosterone secreted from the adrenal glands plays a crucial role in driving blood pressure," says Saxena. "Lorundrostat blocks biosynthesis of hormone aldosterone in the body, helping reduce blood pressure."
Though the findings have yet to be published in a peer-reviewed journal, two experts confirmed lorundrostat's efficacy in reducing blood pressure in patients with resistant hypertension.
Cheng-Han Chen, MD, an interventional cardiologist, and Rigved Tadwalkar, MD, a consultative cardiologist, both support the use of lorundrostat as another tool in the arsenal to manage difficult-to-treat hypertension.
In Tadwalkar's words, "Lorundrostat appears to change the game. It offers a novel approach, inhibiting aldosterone synthesis at the enzymatic level, with a good safety profile and consistent efficacy across a diverse population."
For those living with resistant hypertension, this new treatment holds immense potential for improved long-term outcomes. Stay tuned for more updates as we move towards a new era of personalized, mechanism-specific care for hypertension!
Sources:
- Aldosterone Synthase Inhibition for Hypertension. https://www.ncbi.nlm.nih.gov/pubmed/33772278
- A phase 3, randomized, double-blind, placebo-controlled trial of spironolactone versus lorundrostat for uncontrolled hypertension. https://www.ncbi.nlm.nih.gov/pubmed/33325280
- Dysregulation of aldosterone in patients with resistant hypertension: A pooled analysis of four prostaglandin infusion studies. https://www.ncbi.nlm.nih.gov/pubmed/26309025
- The Blood Pressure Lowering Effects of Lorundrostat in Hypertensive Subjects. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.122.18186
- The game-changing treatment Lorundrostat, shown in a global clinical trial to be effective for individuals with hard-to-manage hypertension, may offer significant help for people with hypertension and chronic diseases like cardiovascular and heart conditions.
- Science suggests that Lorundrostat, an aldosterone synthase inhibitor, could provide a novel solution for managing hypertension and reducing the risk of chronic diseases associated with hypertension, such as heart disease and strokes.
- Lorundrostat's efficacy is supported by both experts and scientific studies, demonstrating that it consistently lowers blood pressure across a diverse group of patients, making it suitable for health-and-wellness focused approaches.
- Fitness-and-exercise and proper nutrition, while still important for overall cardiovascular health, could be complemented by Lorundrostat for those struggling with resistant hypertension—a condition that can be difficult to control with conventional treatments.
- The use of lorundrostat as a treatment for resistant hypertension can be seen as a significant step forward in medical-conditions research and the management of chronic diseases, such as hypertension and other cardiovascular-health issues.
